Topic
This project focuses on the study of living organisms at different scales of observation defined by their size—ranging from the meter to the nanometer—and aims to understand the various levels of organization: from the structure and dynamics of molecules and their role in cellular architecture and signaling, to the integration of these cells into organs and organisms.
We are taking on the challenge of understanding the dynamics of these systems regardless of the scale of observation and aim to integrate these levels of analysis. To this end, we are promoting 1) the development of innovative methodologies and 2) the practical applications made possible by these technological advances to address complex biological questions. Innovations in high-resolution spatial and temporal analysis of living systems in the fields of biology and health will provide solutions to medical and societal challenges. Cutting-edge research and innovation facilitated by these technologies will offer new approaches to disease prevention through novel detection and diagnostic methods, beginning with an understanding of how living organisms function and extending to the underlying causes of disease.
The PTL aims to promote methodological developments in three subthemes that are important for the spatiotemporal analysis of living organisms:
Imaging of living organisms
This involves the design and development of new imaging techniques or high-resolution spatial and temporal analysis methods, from the cellular to the organismal level. The creation of new technologies and innovative methodologies will make it possible to answer the most complex biological questions. The PTL will also support practical applications made possible by these technological advances to solve specific biological problems. To understand the dynamics of systems, regardless of the scale of observation, approaches focusing on living systems will be prioritized.
Developing multiparametric approaches
Develop methods for reading multiple parameters from the same sample and understand how these systems interact and influence one another. The goal is to obtain an integrated view of a complex biological process. The development of appropriate theoretical methods will make it possible to account for the complexity of a signal and to link different scales of observation.
Promoting the Study of Endogenous Systems
The goal is to improve methods for observing biological processes as they occur naturally. This requires minimally invasive techniques that preserve the integrity of the living subject. This may involve addressing the challenges associated with observing endogenous molecules or analyzing macromolecular complexes in their native cellular environment, as well as accurately mapping the spatial location of identified cell subpopulations within their native tissue…